PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant

Clin Infect Dis. 2015 Aug 15;61(4):619-22. doi: 10.1093/cid/civ386. Epub 2015 May 14.

Abstract

Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infections among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patients' risk stratification.

Keywords: PTX3; SNP; genetic susceptibility; innate immunity; solid organ transplant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • C-Reactive Protein / genetics*
  • Female
  • Fungi / isolation & purification*
  • Humans
  • Immunocompromised Host*
  • Male
  • Mycoses / genetics*
  • Mycoses / immunology*
  • Organ Transplantation / adverse effects*
  • Polymorphism, Genetic*
  • Prospective Studies
  • Serum Amyloid P-Component / genetics*

Substances

  • Serum Amyloid P-Component
  • PTX3 protein
  • C-Reactive Protein