Variations in the rate of secretion of different glycosylated forms of rat alpha 1-acid glycoprotein

Biochem J. 1989 Nov 1;263(3):961-4. doi: 10.1042/bj2630961.

Abstract

Various studies have shown that oligosaccharides play an important role in the intracellular transport and secretion of glycoproteins. We show here a difference in the rate of secretion of two mature glycoforms of a single protein, alpha 1-acid glycoprotein. This indicates the existence of kinetically different pathways for these two forms for transport from the medial Golgi to the extracellular medium.

MeSH terms

  • Albumins / metabolism
  • Animals
  • Glycosylation
  • Inflammation / metabolism
  • Liver / metabolism*
  • Male
  • Orosomucoid / metabolism*
  • Protein Processing, Post-Translational
  • Rats
  • Rats, Inbred Strains
  • Receptors, Concanavalin A / analysis
  • Structure-Activity Relationship

Substances

  • Albumins
  • Orosomucoid
  • Receptors, Concanavalin A