The study describes the results of prothrombin time (PT), Anti-thrombin III (AT III) and fibrin polymerization curve (FPC) measured simultaneously in patients with liver disease who were divided into two groups: cirrhotics (n = 37) and miscellaneous liver disease (n = 35). There was significant prolongation of PT in 82% of cirrhotics and in 17% of the miscellaneous liver disease group. In contrast significant reduction of AT III levels was noted in 94% of cirrhotics and 31% of the miscellaneous liver disease group. Abnormal FPC was seen in 88% and 32% respectively. There was a good correlation between PT and AT III levels. It was concluded that AT III measurement is a more sensitive indicator than PT and FPC in the assessment of hepatocellular dysfunction.