Pushing and pulling on adult neural stem cells

Albina Ibrayeva; Michael A Bonaguidi

doi:10.1016/j.stem.2015.04.011

Pushing and pulling on adult neural stem cells

Cell Stem Cell. 2015 May 7;16(5):451-2. doi: 10.1016/j.stem.2015.04.011.

Authors

Albina Ibrayeva¹, Michael A Bonaguidi²

Affiliations

¹ Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, W.M. Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
² Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, W.M. Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: mbonagui@usc.edu.

PMID: 25957896
DOI: 10.1016/j.stem.2015.04.011

Abstract

How plastic is adult neurogenesis? In this issue of Cell Stem Cell, Sierra et al. (2015) use epilepsy models to probe how hippocampal neural stem cells (NSCs) respond to graded pathological conditions. They uncover changes in cell fate potential upon NSC activation, but it comes at a cost.

Publication types

Comment

MeSH terms

Animals
Astrocytes / physiology*
Epilepsy / physiopathology*
Hippocampus / cytology*
Humans
Neural Stem Cells / physiology*
Psychomotor Agitation / physiopathology*

Grants and funding

R00 NS080913/NS/NINDS NIH HHS/United States