1 1Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile Santiago 8330024 Chile, Santiago, Chile 2Department of Obstetrics and Gynecology,Faculty of Medicine Pontificia Universidad Catolica de Chile Santiago Chile, Santiago, Chile 3Biomedical Department,Faculty of Health Sciences Universidad de Antofagasta Anto fagasta Chile, Santiago, Chile.