Nonalcoholic fatty liver disease (NAFLD) is recognized in 20-30% of general population but among the people with impaired glucose metabolism this percentage is about 70-90%. The aim of this study is to assess the determinants of NAFLD with respect to patients' gender. We examined 180 patients, 73 women and 107 men. Increased body mass index (BMI), waist circumference above the norm are the determinants of NAFLD irrespectively to gender. Besides it has been observed that in the women group the increase of HDL-cholesterol by 1 mmol/l decreases the chances of NAFLD occurrence by 90%.