Computer Tomograph (CT) imaging of mandibular anatomical substrate in animal model restored with nanostructured hydroxyapatite compounds

J Med Life. 2015 Jan-Mar;8(1):99-102.

Abstract

Introduction: This study was meant to test a new type of bone graft on an animal model. This material was a nanostructured hydroxyapatite.

Materials and methods: the study was conducted according to Ethic Committee Regulation on animal model (Oryctolagus cuniculus - rabbit) between August and November 2014, at "Carol Davila" University of Medicine and Pharmacy, Bucharest. The animals were tested by using a CT at the level of the mandible before and after using the nanostructured hydroxyapatite.

Results: The animals were CT scanned at 1, 2 and respectively 3 months, noticing a growth of the mandibular bone density. After 3 months, a bone density equal with the density of the healthy bone was noticed.

Conclusions: The use of the bone graft could be a viable alternative to available materials. The advantage was that bone recovery had a density similar to the density of the healthy bone and the cost of production was low because it was made out of Calcium azotate and monobasic ammonium phosphate.

Keywords: bone reconstruction; dental implant; hydroxyapatite; nanostructured polymers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Density / drug effects
  • Durapatite / pharmacology*
  • Imaging, Three-Dimensional*
  • Male
  • Mandible / anatomy & histology*
  • Mandible / diagnostic imaging*
  • Mandible / surgery
  • Models, Animal
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure
  • Rabbits
  • Tomography, X-Ray Computed / methods*

Substances

  • Durapatite