Tackling oxidative stress by a direct route: a new job for HDAC inhibitors?

Luca Sartori; Saverio Minucci

doi:10.1016/j.chembiol.2015.04.003

Tackling oxidative stress by a direct route: a new job for HDAC inhibitors?

Chem Biol. 2015 Apr 23;22(4):431-432. doi: 10.1016/j.chembiol.2015.04.003.

Authors

Luca Sartori¹, Saverio Minucci²

Affiliations

¹ Department of Experimental Oncology, Academic Drug Discovery Program, and Drug Development Program, European Institute of Oncology, Via Adamello, Milan 20139, Italy.
² Department of Experimental Oncology, Academic Drug Discovery Program, and Drug Development Program, European Institute of Oncology, Via Adamello, Milan 20139, Italy; Department of Biosciences, University of Milan, Via Celoria 26, Milan 20100, Italy. Electronic address: saverio.minucci@ieo.eu.

PMID: 25910237
DOI: 10.1016/j.chembiol.2015.04.003

Abstract

Olson et al. (2015) propose that some hydroxamic acid-based small molecules, already in clinical use as histone deacetylase inhibitors, may protect against oxidative stress through a direct chemical reaction of dismutation of hydrogen peroxide into water.

Publication types

Comment

MeSH terms

Animals
Histone Deacetylase Inhibitors / chemistry*
Histone Deacetylases / chemistry*
Hydroxamic Acids / chemistry*
Neurons / metabolism*

Substances

Histone Deacetylase Inhibitors
Hydroxamic Acids
Histone Deacetylases