Epidemiology of vancomycin-resistant enterococci in Canadian hospitals (CANWARD study, 2007 to 2013)

Antimicrob Agents Chemother. 2015 Jul;59(7):4315-7. doi: 10.1128/AAC.00384-15. Epub 2015 Apr 20.

Abstract

Of 1,927 Enterococcus species isolates collected across Canada from 2007 to 2013, 80 (4.2%) were identified as vancomycin-resistant enterococci (VRE). VRE infections during this time tripled in Canadian hospitals, from 1.8% to 6.0% (P = 0.03). All VRE were Enterococcus faecium, with 90% possessing vanA. The prevalence of vanB decreased from 37.5% in 2007 to 0% in 2013 (P < 0.05). The VRE were multidrug resistant, but 70.6%, 86.3%, and 100% were susceptible to doxycycline, linezolid, and daptomycin, respectively.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics
  • Canada / epidemiology
  • Carbon-Oxygen Ligases / genetics
  • Child
  • Child, Preschool
  • Drug Resistance, Multiple, Bacterial / genetics
  • Enterococcus / drug effects*
  • Enterococcus faecium / drug effects
  • Female
  • Gram-Positive Bacterial Infections / epidemiology*
  • Gram-Positive Bacterial Infections / microbiology*
  • Hospitals
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Prevalence
  • Public Health Surveillance
  • Vancomycin / pharmacology
  • Vancomycin Resistance*
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • VanA ligase, Bacteria
  • VanB protein, Enterococcus
  • Vancomycin
  • Carbon-Oxygen Ligases