Expression of vascular endothelial growth factor in Juvenile Angiofibroma

Int J Pediatr Otorhinolaryngol. 2015 Jun;79(6):900-902. doi: 10.1016/j.ijporl.2015.03.033. Epub 2015 Apr 11.

Abstract

Objective: To examine Juvenile Angiofibroma (JA) tissue for expression of vascular endothelial growth factor (VEGF), and to explore its relationship with puberty status, stage, recurrence and the intraoperative blood loss.

Methods: Retrospective cohort study of 36 histologically proven cases of JA. Minimum follow up period was 3 years. VEGF expression on tumor cells assessed by immunohistochemistry and graded on two criteria--percentage of cells expressing positivity and the intensity of positivity. These two parameters assessed for impact on puberty status, stage, recurrence, and blood loss.

Results: VEGF expression noted on the tumor endothelial cells in 36/36, and on the tumor stromal cells in 34/36. The percentage of cells expressing VEGF and the intensity of expression were not significantly related to puberty status, tumor stage, recurrence, or intra-operative blood loss (p values 0.3-1.0).

Conclusion: VEGF expression is near universal in JA. Such expression is independent of puberty status and stage, and does not impact on intra operative blood loss and recurrence.

Keywords: Blood loss; Juvenile Angiofibroma; VEGF.

MeSH terms

  • Adolescent
  • Angiofibroma / metabolism*
  • Angiofibroma / pathology*
  • Angiofibroma / surgery
  • Blood Loss, Surgical
  • Child
  • Endothelial Cells / metabolism
  • Humans
  • Immunohistochemistry
  • Male
  • Neoplasm Recurrence, Local / metabolism*
  • Neoplasm Staging
  • Puberty
  • Retrospective Studies
  • Skull Base Neoplasms / metabolism*
  • Skull Base Neoplasms / pathology*
  • Skull Base Neoplasms / surgery
  • Stromal Cells / metabolism
  • Vascular Endothelial Growth Factor A / metabolism*

Substances

  • Vascular Endothelial Growth Factor A