Abstract
A new theranostic platform is developed based on biocompatible poly(acrylic acid) (PAA)-Co9 Se8 nanoplates. These PAA-Co9 Se8 nanoplates are successfully utilized for photoacoustic imaging (PAI)/magnetic resonance imaging (MRI) dual-modal imaging. Moreover, the PAA-Co9 Se8 -DOX shows pH-responsive chemotherapy and enables the combination of photothermal therapy and chemotherapy to receive superior antitumor efficacy. This work promises further exploration of 2D nanoplatforms for theranostic applications.
Keywords:
chemotherapy; magnetic resonance imaging; nanoplates; photoacoustic imaging; photothermal therapy.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylic Resins / chemical synthesis
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Acrylic Resins / chemistry
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Antineoplastic Agents / administration & dosage
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / chemistry
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Cobalt* / chemistry
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Combined Modality Therapy / instrumentation
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Combined Modality Therapy / methods
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Contrast Media / chemical synthesis
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Contrast Media / chemistry
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Hep G2 Cells
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Humans
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Hydrogen-Ion Concentration
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Magnetic Resonance Imaging / instrumentation*
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Magnetic Resonance Imaging / methods
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Materials Testing
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Multimodal Imaging / instrumentation
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Multimodal Imaging / methods
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Nanostructures* / chemistry
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Neoplasm Transplantation
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Photoacoustic Techniques / instrumentation*
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Photoacoustic Techniques / methods
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Phototherapy / instrumentation
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Phototherapy / methods
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Selenium Compounds* / chemical synthesis
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Selenium Compounds* / chemistry
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Theranostic Nanomedicine / instrumentation*
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Theranostic Nanomedicine / methods
Substances
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Acrylic Resins
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Antineoplastic Agents
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Biocompatible Materials
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Contrast Media
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Selenium Compounds
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Cobalt
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carbopol 940