Thinking big with small molecules

Karen Mruk; James K Chen

doi:10.1083/jcb.201501084

Thinking big with small molecules

J Cell Biol. 2015 Apr 13;209(1):7-9. doi: 10.1083/jcb.201501084.

Authors

Karen Mruk¹, James K Chen²

Affiliations

¹ Department of Chemical and Systems Biology and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 Department of Chemical and Systems Biology and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
² Department of Chemical and Systems Biology and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 Department of Chemical and Systems Biology and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 jameschen@stanford.edu.

Abstract

Synthetic chemistry has enabled scientists to explore the frontiers of cell biology, limited only by the laws of chemical bonding and reactivity. As we investigate biological questions of increasing complexity, new chemical technologies can provide systems-level views of cellular function. Here we discuss some of the molecular probes that illustrate this shift from a "one compound, one gene" paradigm to a more integrated approach to cell biology.

Thinking big with small molecules

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