Failure of azithromycin 2.0 g in the treatment of gonococcal urethritis caused by high-level resistance in California

Sex Transm Dis. 2015 May;42(5):279-80. doi: 10.1097/OLQ.0000000000000265.

Abstract

We report a treatment failure to azithromycin 2.0 g caused by a urethral Neisseria gonorrhoeae isolate with high-level azithromycin resistance in California. This report describes the epidemiological case investigation and phenotypic and genetic characterization of the treatment failure isolate.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / administration & dosage*
  • Azithromycin / pharmacology*
  • California / epidemiology
  • Ceftriaxone / administration & dosage*
  • Contact Tracing
  • Drug Resistance, Bacterial
  • Female
  • Gonorrhea / drug therapy*
  • Gonorrhea / genetics
  • Gonorrhea / microbiology
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Neisseria gonorrhoeae / drug effects*
  • Neisseria gonorrhoeae / genetics
  • Population Surveillance
  • Treatment Failure
  • United States / epidemiology
  • Urethritis / drug therapy*
  • Urethritis / etiology
  • Urethritis / genetics

Substances

  • Anti-Bacterial Agents
  • Ceftriaxone
  • Azithromycin