H₈-BINOL chiral imidodiphosphoric acid catalyzed highly enantioselective aza-Friedel-Crafts reactions of pyrroles and enamides/imines

Chem Commun (Camb). 2015 May 11;51(38):8054-7. doi: 10.1039/c5cc00685f. Epub 2015 Apr 13.

Abstract

The first enantioselective aza-Friedel-Crafts reaction between pyrroles and enamides has been achieved by using a novel H8-BINOL-type imidodiphosphoric acid catalyst. This methodology was also applied to the highly enantioselective aza-Friedel-Crafts reaction between pyrroles and imines. The catalyst loadings in these two reactions are low (0.3-2 mol%). Both processes are amenable to gram scales.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Amines / chemical synthesis*
  • Amines / chemistry
  • Catalysis
  • Diphosphonates / chemistry*
  • Imines / chemistry*
  • Molecular Structure
  • Naphthols / chemistry*
  • Pyrroles / chemistry*
  • Stereoisomerism

Substances

  • Amides
  • Amines
  • BINOL, naphthol
  • Diphosphonates
  • Imines
  • Naphthols
  • Pyrroles
  • imidodiphosphonic acid