The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases

Nidhi Garg; Stephen W Reddel; David H Miller; Jeremy Chataway; D Sean Riminton; Yael Barnett; Lynette Masters; Michael H Barnett; Todd A Hardy

doi:10.1136/jnnp-2014-309649

The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases

J Neurol Neurosurg Psychiatry. 2015 Dec;86(12):1374-82. doi: 10.1136/jnnp-2014-309649. Epub 2015 Apr 9.

Authors

Nidhi Garg¹, Stephen W Reddel¹, David H Miller², Jeremy Chataway², D Sean Riminton¹, Yael Barnett³, Lynette Masters⁴, Michael H Barnett⁵, Todd A Hardy⁶

Affiliations

¹ Neuroimmunology Clinic, Concord Hospital and University of Sydney, Sydney, New South Wales, Australia.
² Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK.
³ Department of Radiology, St Vincent's Hospital, Sydney, New South Wales, Australia Sydney Neuroimaging Analysis Centre, Sydney, New South Wales, Australia.
⁴ Department of Neuroradiology, Southern Radiology, Miranda, Australia.
⁵ Sydney Neuroimaging Analysis Centre, Sydney, New South Wales, Australia Brain & Mind Research Institute, University of Sydney, New South Wales, Australia.
⁶ Neuroimmunology Clinic, Concord Hospital and University of Sydney, Sydney, New South Wales, Australia Brain & Mind Research Institute, University of Sydney, New South Wales, Australia.

PMID: 25857658
DOI: 10.1136/jnnp-2014-309649

Abstract

Lesions in the corpus callosum (CC) are important radiological clues to the diagnosis of multiple sclerosis (MS), but may also occur in other neuroinflammatory and non-neuroinflammatory conditions. In this article, we discuss the radiological features of lesions within the CC in MS and other central nervous system inflammatory and acquired demyelinating diseases. An understanding of the appearance and location of lesions in the CC is important not only for accurate diagnosis and treatment of these various conditions, but as it also provides insights into pathogenesis.

Keywords: MRI; MULTIPLE SCLEROSIS; NEUROIMMUNOLOGY; VASCULITIS.

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Publication types

Review

MeSH terms

Corpus Callosum / pathology*
Demyelinating Diseases / diagnosis
Demyelinating Diseases / pathology*
Encephalitis / diagnosis
Encephalitis / pathology*
Humans
Magnetic Resonance Imaging
Multiple Sclerosis / diagnosis
Multiple Sclerosis / pathology*