Facile synthesis and stereo-resolution of chiral 1,2,3-triazoles

Org Biomol Chem. 2015 May 21;13(19):5407-11. doi: 10.1039/c5ob00479a.

Abstract

We describe herein the first facile synthesis of chiral triazoles through side chain functionalization. Readily available C-vinyl triazoles were used as starting materials, followed by sequential epoxidation, rearrangement and reduction to give the corresponding hydroxyl-triazoles. The CalB lipase catalyzed kinetic resolution gave enantiomerically pure (>99% ee) chiral triazoles in excellent yield. These new chiral TAs were also successfully applied as ligands in asymmetric addition of diethylzinc to aldehydes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Alkenes / chemistry
  • Cyclohexanes / chemistry
  • Hydroxylation
  • Kinetics
  • Ligands
  • Organometallic Compounds / chemistry
  • Stereoisomerism
  • Triazoles / chemical synthesis*
  • Triazoles / chemistry*

Substances

  • Aldehydes
  • Alkenes
  • Cyclohexanes
  • Ligands
  • Organometallic Compounds
  • Triazoles
  • diethylzinc