Effects of sitagliptin on the serum creatinine in Japanese type 2 diabetes

Hajime Maeda; Akira Kubota; Akira Kanamori; Yasushi Tanaka; Yasuo Terauchi; Ikuro Matsuba; Study Group of Diabetes Committee, Kanagawa Physicians Association

doi:10.1016/j.diabres.2015.03.008

Effects of sitagliptin on the serum creatinine in Japanese type 2 diabetes

Diabetes Res Clin Pract. 2015 Jun;108(3):e42-5. doi: 10.1016/j.diabres.2015.03.008. Epub 2015 Mar 16.

Authors

Hajime Maeda¹, Akira Kubota², Akira Kanamori², Yasushi Tanaka³, Yasuo Terauchi⁴, Ikuro Matsuba²; Study Group of Diabetes Committee, Kanagawa Physicians Association

Collaborators

Study Group of Diabetes Committee, Kanagawa Physicians Association:
Kiyokazu Matoba, Yasuyuki Jin, Fuyuki Minagawa, Mitsuo Obana, Koutaro Iemitsu, Syogo Ito, Hikaru Amemiya, Mizuki Kaneshiro, Masahiko Takai, Hideaki Kaneshige, Kazuhiko Hoshino, Masashi Ishikawa, Nobuaki Minami, Tetsuro Takuma, Nobuo Sasai, Sachio Aoyagi, Takehiro Kawata, Atsuko Mokubo, Hiroshi Takeda, Shin Honda, Hideo Machimura, Tetsuya Motomiya, Manabu Waseda, Yukiko Miyairi

Affiliations

¹ The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3F Kanagawa-ken Sogo Iryo Kaikan, 3-1 Fujimi-cho, Naka-ku, Yokohama-city, Kanagawa 231 0037, Japan. Electronic address: hec@asahi-net.email.ne.jp.
² The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3F Kanagawa-ken Sogo Iryo Kaikan, 3-1 Fujimi-cho, Naka-ku, Yokohama-city, Kanagawa 231 0037, Japan.
³ Department of Internal Medicine, Division of Metabolism and Endocrinology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa 216 8511, Japan.
⁴ Department of Endocrinology and Metabolism, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama-city, Kanagawa 236 0004, Japan.

PMID: 25836945
DOI: 10.1016/j.diabres.2015.03.008

Abstract

We found a slight elevation of serum creatinine in the subjects treated with sitagliptin for 2 years and a correlation between creatinine elevation and HbA1c reduction. These results suggest that creatinine elevation is associated with activation of incretin, most possibly with up-regulation of diuretic activity of GLP-1.

Keywords: Creatinine; Dipeptidyl peptidase-4 (DPP-4) inhibitor; HbA1c; Sitagliptin.

Publication types

Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Creatinine / blood*
Diabetes Mellitus, Type 2 / blood*
Diabetes Mellitus, Type 2 / drug therapy*
Diabetes Mellitus, Type 2 / ethnology
Dipeptidyl-Peptidase IV Inhibitors / therapeutic use*
Female
Glucagon-Like Peptide 1 / blood
Glycated Hemoglobin / metabolism
Humans
Japan / epidemiology
Male
Middle Aged
Retrospective Studies
Sitagliptin Phosphate / therapeutic use*

Substances

Dipeptidyl-Peptidase IV Inhibitors
Glycated Hemoglobin A
hemoglobin A1c protein, human
Glucagon-Like Peptide 1
Creatinine
Sitagliptin Phosphate