An alternative way to initiate Notch1 signaling in non-small cell lung cancer

Yi-Lin Yang; David Jablons; Liang You

doi:10.3978/j.issn.2218-6751.2013.12.06

An alternative way to initiate Notch1 signaling in non-small cell lung cancer

Transl Lung Cancer Res. 2014 Aug;3(4):238-41. doi: 10.3978/j.issn.2218-6751.2013.12.06.

Authors

Yi-Lin Yang¹, David Jablons¹, Liang You¹

Affiliation

¹ Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA.

PMID: 25806306
PMCID: PMC4367706
DOI: 10.3978/j.issn.2218-6751.2013.12.06

Abstract

Non-small cell lung cancer (NSCLC) cells activate Notch1 signaling to promote cell proliferation and facilitate their survival. It now emerges that endothelial Delta-like ligand 4 (Dll4) may mediate Notch1 activation and inhibit tumor cell growth.

Keywords: Delta-like ligand 4 (Dll4); Notch signaling; non-small cell lung cancer (NSCLC).

Grants and funding

R01 CA140654/CA/NCI NIH HHS/United States