New lignans from the roots of Schisandra sphenanthera

Kan Jiang; Qiu-Yan Song; Shou-Jiao Peng; Qian-Qian Zhao; Guang-Da Li; Ya Li; Kun Gao

doi:10.1016/j.fitote.2015.03.015

New lignans from the roots of Schisandra sphenanthera

Fitoterapia. 2015 Jun:103:63-70. doi: 10.1016/j.fitote.2015.03.015. Epub 2015 Mar 19.

Authors

Kan Jiang¹, Qiu-Yan Song¹, Shou-Jiao Peng¹, Qian-Qian Zhao¹, Guang-Da Li¹, Ya Li², Kun Gao³

Affiliations

¹ State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
² State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: liea@lzu.edu.cn.
³ State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China; School of Biotechnology and Chemical Engineering, Ningbo Institute of Technology, Zhejiang University; Ningbo 315100, People's Republic of China. Electronic address: npchem@lzu.edu.cn.

PMID: 25796351
DOI: 10.1016/j.fitote.2015.03.015

Abstract

Nine new lignans (1-8, 13) and five known ones (9-12, 14) have been isolated from the roots of Schisandra sphenanthera and were tested for their capacity to scavenge 2,2-diphenyl-1-Picryl-hydrazyl (DPPH). Of these lignans tested, compounds 1, 7, 8 and 13 exhibited noteworthy antioxidant activity with IC50 values of 92, 115, 35 and 48 μg/mL, respectively. The anti-oxidative haemolysis of human red blood cells (RBCs) activity of the most active compound 8, which is similar to that of vitamin C, was evaluated.

Keywords: Antioxidant activity; Lignans; RBCs; Schisandra sphenanthera.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Erythrocytes / drug effects*
Free Radical Scavengers / chemistry
Hemolysis
Humans
Inhibitory Concentration 50
Lignans / chemistry*
Lignans / isolation & purification
Molecular Structure
Plant Roots / chemistry*
Schisandra / chemistry*

Substances

Free Radical Scavengers
Lignans