Consequences of Disrupted Notch Signaling in Bladder Cancer

Annemarie Greife; Michèle J Hoffmann; Wolfgang A Schulz

doi:10.1016/j.eururo.2015.02.034

Consequences of Disrupted Notch Signaling in Bladder Cancer

Eur Urol. 2015 Jul;68(1):3-4. doi: 10.1016/j.eururo.2015.02.034. Epub 2015 Mar 16.

Authors

Annemarie Greife¹, Michèle J Hoffmann¹, Wolfgang A Schulz²

Affiliations

¹ Department of Urology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
² Department of Urology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address: wolfgang.schulz@uni-duesseldorf.de.

PMID: 25791514
DOI: 10.1016/j.eururo.2015.02.034

Abstract

The Notch pathway, which controls stem cell maintenance and cell differentiation, is activated in certain cancers and therefore constitutes a therapeutic target. Especially in invasive urothelial carcinoma, the pathway is inactivated instead, and drugs inhibiting Notch signaling are likely contra-indicated.

Publication types

Editorial
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Female
Humans
Male
Receptors, Notch / metabolism*
Tumor Suppressor Proteins / metabolism*
Urinary Bladder Neoplasms / metabolism*

Substances

Receptors, Notch
Tumor Suppressor Proteins