Self-assembled autophagy-inducing polymeric nanoparticles for breast cancer interference in-vivo

Adv Mater. 2015 Apr 24;27(16):2627-34. doi: 10.1002/adma.201405926. Epub 2015 Mar 18.

Abstract

A peptide-conjugated poly(β-amino ester) that self-assembles into micelle-like nanoparticles is prepared by a convenient and modular supramolecular approach. The polymer-beclin-1 (P-Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach overcomes two major limitations of the haploinsufficient tumor suppressor Bec1 compared to small-molecule drugs: poor delivery to tumors owing to enzymatic degradation, and unstable, non-specific bio-distribution and targeting in the tumor tissues.

Keywords: breast cancer; nanoparticles; polymer; self-assembly; therapeutic peptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylates / chemistry
  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Apoptosis Regulatory Proteins / administration & dosage*
  • Apoptosis Regulatory Proteins / chemistry
  • Autophagy* / physiology
  • Beclin-1
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / physiopathology
  • Cell Line, Tumor
  • Drug Delivery Systems
  • Humans
  • Hydrogen-Ion Concentration
  • Hydrophobic and Hydrophilic Interactions
  • Lysosomes / drug effects
  • Lysosomes / metabolism
  • Membrane Proteins / administration & dosage*
  • Membrane Proteins / chemistry
  • Mice, Nude
  • Micelles
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Neoplasm Transplantation
  • Polyethylene Glycols / chemistry
  • Polymers / chemistry
  • Protein Stability
  • Protein Structure, Secondary

Substances

  • Acrylates
  • Antineoplastic Agents
  • Apoptosis Regulatory Proteins
  • BECN1 protein, human
  • Beclin-1
  • Membrane Proteins
  • Micelles
  • Polymers
  • poly(beta-amino ester)
  • Polyethylene Glycols
  • 1,6-hexanediol diacrylate