Selective detection of tyrosine-containing proximally phosphorylated motifs using an antenna-free Tb³⁺ luminescent sensor

Chem Commun (Camb). 2015 Apr 18;51(30):6675-7. doi: 10.1039/c5cc00679a.

Abstract

We herein report the first application of Tb(3+) for the selective detection of an important subset of the phosphoproteome, namely, proximally di-phosphorylated peptide motifs where at least one phosphorylated residue is tyrosine.

MeSH terms

  • Amino Acid Motifs
  • Chemistry Techniques, Analytical / instrumentation*
  • Luminescent Measurements
  • Models, Molecular
  • Phosphoproteins / analysis*
  • Phosphoproteins / chemistry*
  • Phosphorylation
  • Terbium / chemistry*
  • Tyrosine*

Substances

  • Phosphoproteins
  • Terbium
  • Tyrosine