Bionic approach for the prevention of exit-site infections of percutaneous devices

Biomed Tech (Berl). 2015 Jun;60(3):225-33. doi: 10.1515/bmt-2014-0062.

Abstract

Exit-site infections remain one of the main complications for percutaneous devices, such as catheters for peritoneal dialysis or drivelines for ventricular assist devices. Many efforts have been made to create a biological seal, yet without long-term success. This study investigates a new kind of percutaneous device which is coated with an extricable polymeric membrane. The bionic approach applies the naturally outwards directed growth of skin structures to technology: by pulling the protective membrane it slowly grows out of the body and a developing sulcus is exposed to dry air and an infection is avoided. In a feasibility study this kind of device was shown to reduce the rate of infection. To further investigate these devices, they were implanted in the skin of goats and observed for a period of more than 500 days. The membranes were pulled with a force of up to 2 N and the resulting movement was recorded. When being pulled, the membranes moved 0.4-0.9 mm per week, showing that the application of a continuously acting, defined force on the protective membrane causes the desired slow movement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bionics / instrumentation*
  • Catheters / microbiology*
  • Catheters / standards
  • Heart-Assist Devices / microbiology*
  • Infection Control / instrumentation*
  • Peritoneal Dialysis / instrumentation*
  • Skin / chemistry*
  • Skin / cytology*