Spontaneous isolated superior mesenteric artery dissection: genetic heterogeneity of chromosome locus 5q13-14 in 2 male familial cases

Ann Vasc Surg. 2015 Jul;29(5):1019.e1-5. doi: 10.1016/j.avsg.2015.01.030. Epub 2015 Mar 11.

Abstract

Spontaneous isolated superior mesenteric artery dissection (SISMAD) is a rare disease that occurs sporadically. In this report, we describe 2 cases of SISMAD involving an uncle and his nephew. Genetic studies revealed the presence of heterogeneity of a chromosome locus at 5q13-14 in 3 family members (the 2 patients and the nephew's mother), an area previously found to be linked to familial ascending aortic aneurysms and dissections.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angiography
  • Aortic Dissection / diagnosis
  • Aortic Dissection / genetics*
  • Aortic Dissection / surgery
  • Chromosomes, Human, Pair 5 / genetics*
  • Endovascular Procedures / methods*
  • Genetic Heterogeneity
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Mesenteric Artery, Superior*
  • Middle Aged
  • Pedigree
  • Tomography, X-Ray Computed