Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy

Exp Cell Res. 2015 May 1;333(2):195-200. doi: 10.1016/j.yexcr.2015.02.025. Epub 2015 Mar 11.
No abstract available

Keywords: Ceramide; Sphingolipid rheostat; Sphingosine kinase; Sphingosine-1-phosphate.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Cell Transformation, Neoplastic / metabolism
  • Ceramides / physiology
  • Humans
  • Lysophospholipids / physiology*
  • Molecular Targeted Therapy
  • Neoplasms / drug therapy
  • Neoplasms / metabolism*
  • Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism
  • Receptors, Lysophospholipid / metabolism
  • Signal Transduction
  • Sphingosine / analogs & derivatives*
  • Sphingosine / physiology

Substances

  • Antineoplastic Agents
  • Ceramides
  • Lysophospholipids
  • Receptors, Lysophospholipid
  • sphingosine 1-phosphate
  • Phosphotransferases (Alcohol Group Acceptor)
  • sphingosine kinase
  • Sphingosine