Prenatal diagnosis of trisomy 6q25.3-qter and monosomy 10q26.12-qter by array CGH in a fetus with an apparently normal karyotype

Clin Case Rep. 2015 Feb;3(2):92-5. doi: 10.1002/ccr3.162. Epub 2014 Oct 15.

Abstract

We present the prenatal case of a 12.5-Mb duplication involving 6q25-qter and a 12.2-Mb deletion encompassing 10q26-qter diagnosed by aCGH, while conventional karyotype showed normal results. The genotype-phenotype correlation between individual microarray and clinical findings adds to the emerging atlas of chromosomal abnormalities associated with specific prenatal ultrasound abnormalities.

Keywords: Array CGH; deletion 10q; duplication 6q; fetal ultrasound; prenatal diagnosis; unbalanced translocation.

Publication types

  • Case Reports