Immune response elicited by the oral administration of an intermediate strain of IBDV in chickens

Braz J Microbiol. 2015 Mar 4;45(4):1521-5. doi: 10.1590/s1517-83822014000400049. eCollection 2014.

Abstract

The immune response elicited by the oral inoculation of an intermediate strain of infectious bursal disease virus was studied in chickens. A strong over expression of IL-6, IL-8, IFNα and IFNγ was observed in bursa at 3 days post inoculation together with an increase in splenic NO2 release. An influx of T-lymphocytes was also detected.

Keywords: Infectious Bursal Disease virus; RT-qPCR; avian cytokines; flow cytometry; innate immunity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Birnaviridae Infections / immunology
  • Birnaviridae Infections / veterinary*
  • Bursa of Fabricius / pathology
  • Chickens*
  • Cytokines / analysis
  • Cytokines / genetics
  • Gene Expression Profiling
  • Infectious bursal disease virus / immunology*
  • Nitric Oxide / analysis
  • Poultry Diseases / immunology*
  • Spleen / pathology
  • T-Lymphocytes / immunology

Substances

  • Cytokines
  • Nitric Oxide