Abstract
We report for the first time Rotarix vaccine-acquired rotavirus infections with viremia in 2 infants vaccinated before being diagnosed with severe combined immune deficiency. Monitoring the first infant revealed that persistent rotavirus infection resolved after complete immune reconstitution was achieved by gene therapy.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Female
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Genetic Therapy
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Humans
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Infant
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Lymphocyte Count
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Male
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Rotavirus / physiology*
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Rotavirus Vaccines / adverse effects*
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Severe Combined Immunodeficiency / diagnosis
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Severe Combined Immunodeficiency / immunology*
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Severe Combined Immunodeficiency / therapy
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Severe Combined Immunodeficiency / virology*
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Viral Load
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Viremia*
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Virus Shedding*