Assessment of an innovative antimicrobial surface disinfectant in the operating room environment using adenosine triphosphate bioluminescence assay

Am J Infect Control. 2015 Mar 1;43(3):283-5. doi: 10.1016/j.ajic.2014.11.023.

Abstract

Terminal cleaning in the operating room is a critical step in preventing the transmission of health care-associated pathogens. The persistent disinfectant activity of a novel isopropyl alcohol/organofunctional silane solution (ISO) was evaluated in 4 operating rooms after terminal cleaning. Adenosine triphosphate bioluminescence documented a significant difference (P < .048) in surface bioburden on IOS-treated surfaces versus controls. RODAC plate cultures revealed a significant (P < .001) reduction in microbial contamination on IOS-treated surfaces compared with controls. Further studies are warranted to validate the persistent disinfectant activity of ISO within selective health care settings.

Keywords: Adenosine triphosphate bioluminescence assay; Isopropyl alcohol/organofunctional silane solution; Operating room; RODAC plate counts; Terminal cleaning.

MeSH terms

  • 2-Propanol / pharmacology
  • Adenosine Triphosphate / analysis
  • Disinfectants / pharmacology*
  • Environmental Microbiology*
  • Health Services Research*
  • Humans
  • Infection Control / methods*
  • Luminescent Measurements / methods
  • Operating Rooms*
  • Silanes / pharmacology

Substances

  • Disinfectants
  • Silanes
  • Adenosine Triphosphate
  • 2-Propanol