Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice

Shigeru Hasebe; Naoki Hiramatsu; Yukio Ago; Kazuya Mori; Yuji Watabe; Hitoshi Hashimoto; Kazuhiro Takuma; Toshio Matsuda

doi:10.1016/j.jphs.2015.01.001

Role of the 5-HT1A autoreceptor in the enhancement of fluvoxamine-induced increases in prefrontal dopamine release by adrenalectomy/castration in mice

J Pharmacol Sci. 2015 Feb;127(2):232-5. doi: 10.1016/j.jphs.2015.01.001. Epub 2015 Jan 13.

Authors

Shigeru Hasebe¹, Naoki Hiramatsu¹, Yukio Ago¹, Kazuya Mori¹, Yuji Watabe¹, Hitoshi Hashimoto², Kazuhiro Takuma³, Toshio Matsuda⁴

Affiliations

¹ Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871, Japan.
² Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan; iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
³ Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871, Japan; Deptartment of Pharmacology, Graduate School of Dentistry, Osaka University, 1-8 Yamada-oka, Suita, Osaka, 565-0871, Japan.
⁴ Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan. Electronic address: Matsuda@phs.osaka-u.ac.jp.

PMID: 25727963
DOI: 10.1016/j.jphs.2015.01.001

Abstract

We have found that fluvoxamine-induced increases in prefrontal dopamine release are enhanced by adrenalectomy/castration and 5-HT1A receptors are involved in the enhancement. This study examined which 5-HT1A autoreceptors or postsynaptic receptor play a key role in the enhancement in mice. Adrenalectomy/castration-induced enhancement of fluvoxamine-induced increase in the dopamine release was not blocked by local perfusion with the 5-HT1A receptor antagonist WAY100635 (10 μM), while it was blocked by systemic administration of WAY100635 at low dose (0.1 mg/kg) which blocked preferentially autoreceptor-mediated responses. These finding suggests that 5-HT1A autoreceptors play a key role in the enhancement of prefrontal dopamine release.

Keywords: 5-HT(1A) autoreceptor; Prefrontal dopamine release; WAY100635.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adrenalectomy*
Animals
Castration*
Dopamine / metabolism*
Fluvoxamine / pharmacology*
Male
Mice, Inbred Strains
Piperazines / administration & dosage
Piperazines / pharmacology
Prefrontal Cortex / metabolism*
Pyridines / administration & dosage
Pyridines / pharmacology
Receptor, Serotonin, 5-HT1A / physiology*
Selective Serotonin Reuptake Inhibitors / pharmacology*
Serotonin 5-HT1 Receptor Antagonists / administration & dosage
Serotonin 5-HT1 Receptor Antagonists / pharmacology

Substances

Piperazines
Pyridines
Serotonin 5-HT1 Receptor Antagonists
Serotonin Uptake Inhibitors
Receptor, Serotonin, 5-HT1A
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
Fluvoxamine
Dopamine