Preclinical target validation using patient-derived cells

Aled M Edwards; Cheryl H Arrowsmith; Chas Bountra; Mark E Bunnage; Marc Feldmann; Julian C Knight; Dhavalkumar D Patel; Panagiotis Prinos; Michael D Taylor; Michael Sundström; SGC Open Source Target-Discovery Partnership

doi:10.1038/nrd4565

Preclinical target validation using patient-derived cells

Nat Rev Drug Discov. 2015 Mar;14(3):149-50. doi: 10.1038/nrd4565. Epub 2015 Feb 20.

Affiliations

¹ Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
² 1] Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada. [2] Princess Margaret Cancer Centre, University Health Network, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
³ Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7LD, UK.
⁴ Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, USA.
⁵ Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7FY, UK.
⁶ Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
⁷ Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.
⁸ Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
⁹ Structural Genomics Consortium, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, 171 76 Stockholm, Sweden.

PMID: 25722227
DOI: 10.1038/nrd4565

Abstract

The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies.

MeSH terms

Cell Line*
Drug Evaluation, Preclinical / methods*
Humans
Patients
Primary Cell Culture*
Public-Private Sector Partnerships
Translational Research, Biomedical