MEMS: Enabled Drug Delivery Systems

Angelica Cobo; Roya Sheybani; Ellis Meng

doi:10.1002/adhm.201400772

MEMS: Enabled Drug Delivery Systems

Adv Healthc Mater. 2015 May;4(7):969-82. doi: 10.1002/adhm.201400772. Epub 2015 Feb 20.

Authors

Angelica Cobo¹, Roya Sheybani¹, Ellis Meng^{1

2}

Affiliations

¹ Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, 1042 Downey Way DRB-140, Los Angeles, CA, 90089-1111, USA.
² Department of Electrical Engineering, Viterbi School of Engineering, University of Southern California, 3651 Watt Way VHE-602, Los Angeles, CA, 90089-0241, USA.

PMID: 25703045
DOI: 10.1002/adhm.201400772

Abstract

Drug delivery systems play a crucial role in the treatment and management of medical conditions. Microelectromechanical systems (MEMS) technologies have allowed the development of advanced miniaturized devices for medical and biological applications. This Review presents the use of MEMS technologies to produce drug delivery devices detailing the delivery mechanisms, device formats employed, and various biomedical applications. The integration of dosing control systems, examples of commercially available microtechnology-enabled drug delivery devices, remaining challenges, and future outlook are also discussed.

Keywords: drug delivery; microelectromechanical systems; micropumps.

Publication types

Review

MeSH terms

Animals
Drug Delivery Systems / instrumentation*
Drug Delivery Systems / methods*
Equipment Design / instrumentation
Equipment Design / methods
Humans
Micro-Electrical-Mechanical Systems / instrumentation*
Micro-Electrical-Mechanical Systems / methods*
Microtechnology / instrumentation
Microtechnology / methods