A new path to leukemia with WIT

Mol Cell. 2015 Feb 19;57(4):573-574. doi: 10.1016/j.molcel.2015.02.005.

Abstract

In this issue, Wang et al., 2015 describes that WT1 recruits TET2 to the DNA, an important feature of a new regulatory pathway linked to the development of acute myeloid leukemia (AML). This pathway consists of WT1, IDH1/2, and TET2 (WIT) genes, with exclusive mutations of the three genes inducing myeloid cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • DNA-Binding Proteins / physiology*
  • Dioxygenases
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Proto-Oncogene Proteins / physiology*
  • WT1 Proteins / physiology*

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • WT1 Proteins
  • WT1 protein, human
  • Dioxygenases
  • TET2 protein, human