Reduction-responsive dithiomaleimide-based nanomedicine with high drug loading and FRET-indicated drug release

Chem Commun (Camb). 2015 Mar 21;51(23):4807-10. doi: 10.1039/c5cc00148j.

Abstract

Dithiomaleimide-based camptothecin-containing nanoparticles are designed to have exceptionally high drug loading and are capable of reduction-responsive, FRET-indicated drug release.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents
  • Camptothecin / chemistry*
  • Drug Liberation
  • Fluorescence Resonance Energy Transfer
  • Maleimides / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Nanotechnology*

Substances

  • Antineoplastic Agents
  • Maleimides
  • Camptothecin