Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acids

Chem Commun (Camb). 2015 Mar 14;51(21):4496-8. doi: 10.1039/c4cc09780g.

Abstract

A new methodology for the synthesis of side chain mono- or bis-methylated Fmoc-Dap, -Dab and -Orn amino acids was developed by probing the reactivity of commercially available Fmoc amino acids.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acids / chemical synthesis
  • Amino Acids / chemistry*
  • Aminobutyrates / chemistry*
  • Methylation
  • Ornithine / chemistry*
  • beta-Alanine / analogs & derivatives*
  • beta-Alanine / chemistry

Substances

  • Amino Acids
  • Aminobutyrates
  • beta-Alanine
  • 2,4-diaminobutyric acid
  • 2,3-diaminopropionic acid
  • Ornithine