Seizing upon mechanisms for impaired consciousness

Zoya Farzampour; John Huguenard

doi:10.1016/j.neuron.2015.01.023

Seizing upon mechanisms for impaired consciousness

Neuron. 2015 Feb 4;85(3):453-5. doi: 10.1016/j.neuron.2015.01.023.

Authors

Zoya Farzampour¹, John Huguenard²

Affiliations

¹ Stanford Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Stanford Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: John.Huguenard@Stanford.Edu.

Abstract

Transient loss of consciousness associated with focal temporal lobe seizures is a complex phenomenon with life-threatening repercussions. In this issue of Neuron, Motelow et al. (2015) describe decreased cholinergic drive and suppressed subcortical arousal in seizures as a novel mechanism for impaired cortical function.

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MeSH terms

Animals
Arousal*
Cholinergic Neurons / metabolism*
Female
Seizures / metabolism*
Seizures / physiopathology*

Abstract

Publication types

MeSH terms

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