Polymerase chain reaction for detection of dissemination in gastric lymphoma

Lancet. 1989 Apr 1;1(8640):695-7. doi: 10.1016/s0140-6736(89)92208-3.

Abstract

The polymerase chain reaction (PCR) was used to detect malignant lymphoma cells with the bcl-2 gene rearrangement in the peritoneal washings and bone marrow of a patient with an apparently localised gastric lymphoma. After four courses of cytotoxic drug treatment the cells could no longer be detected in either site. PCR is a useful addition to the staging investigations of non-Hodgkin lymphoma and can also be used to monitor response to treatment.

Publication types

  • Case Reports

MeSH terms

  • B-Lymphocytes
  • Bone Marrow Examination
  • Chromosome Mapping
  • DNA, Neoplasm / analysis
  • DNA-Directed DNA Polymerase*
  • Drug Evaluation
  • Humans
  • Lymphoma, Non-Hodgkin / genetics
  • Lymphoma, Non-Hodgkin / pathology*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Oligonucleotide Probes
  • Peritoneal Lavage
  • Proto-Oncogene Proteins / analysis
  • Stomach Neoplasms / genetics
  • Stomach Neoplasms / pathology*
  • Translocation, Genetic

Substances

  • DNA, Neoplasm
  • Oligonucleotide Probes
  • Proto-Oncogene Proteins
  • DNA-Directed DNA Polymerase