Insights into a microwave susceptible agent for minimally invasive microwave tumor thermal therapy

Biomaterials. 2015 Mar:44:91-102. doi: 10.1016/j.biomaterials.2014.12.035. Epub 2015 Jan 12.

Abstract

This work develops a kind of sodium alginate (SA) microcapsules as microwave susceptible agents for in vivo tumor microwave thermal therapy for the first time. Due to the excellent microwave susceptible properties and low bio-toxicity, excellent therapy efficiency can be achieved with the tumor inhibiting ratio of 97.85% after one-time microwave thermal therapy with ultralow power (1.8 W, 450 MHz). Meanwhile, the mechanism of high microwave heating efficiency was confirmed via computer-simulated model in theory, demonstrating that the spatial confinement efficiency of microcapsule walls endows the inside ions with high microwave susceptible properties. This strategy offers tremendous potential applications in clinical tumor treatment with the benefits of safety, reliability, effectiveness and minimally invasiveness.

Keywords: Microcapsule; Microwave; Sodium alginate; Thermal therapy; Tumor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Capsules
  • Cell Death
  • Cell Survival
  • Computer Simulation
  • Female
  • Heating
  • Hemolysis
  • Hep G2 Cells
  • Humans
  • Hyperthermia, Induced / methods*
  • Injections, Subcutaneous
  • Mice, Inbred ICR
  • Microscopy, Electron, Scanning
  • Microwaves*
  • Neoplasms / therapy*
  • Particle Size
  • Rabbits
  • Thermogravimetry
  • Toxicity Tests

Substances

  • Capsules