[Mecanisms of pharmacokinetic interactions involving oral anticancer agents]

Abstract

Oral anticancer agents and particularly kinase inhibitors are subject to pharmacokinetic drug interactions in relation to absorption and elimination phases. Interacting factors are food, fruit juices, cigarette smoke, acid-reducing agents and inducers/inhibitors. Some anticancer agents are inducers and/or inhibitors and can also perpetrate drug interactions. This review emphasizes the mechanisms of pharmacokinetic drug interactions involving oral anticancer agents.

Keywords: Agents anticancéreux oraux; Drug interaction; Interaction médicamenteuses; Oral anticancer agents; Pharmacocinétique; Pharmacokinetics.