Acute Kidney Injury in Elderly Patients With Non-ST Elevation Acute Coronary Syndrome: Insights From the Italian Elderly: ACS Study

Angiology. 2015 Oct;66(9):826-30. doi: 10.1177/0003319714567738. Epub 2015 Jan 15.

Abstract

We examined the incidence and predictors of acute kidney injury (AKI) in elderly patients (≥75 years) enrolled in the prospective Italian Elderly acute coronary syndrome (ACS) study and explored the impact of AKI on clinical outcome. Acute kidney injury, defined according to the Acute Kidney Injury Network criteria, occurred in 128 (21%) of 615 patients. Patients submitted to coronary angiographic procedures did not present higher rate of AKI. The only baseline variables independently associated with AKI development were creatinine clearance (odds ratio [OR]: 0.98; 95% confidence interval [CI]: 0.97-0.99) and left ventricular ejection fraction (OR: 0.98; 95% CI: 0.96-0.99). Adverse clinical events were significantly higher in patients who developed AKI. After multivariable adjustment, AKI (hazard ratio: 2.73; 95% CI: 1.87-4.0) was an independent predictor of all-cause mortality within 1 year.

Trial registration: ClinicalTrials.gov NCT00510185.

Keywords: acute coronary syndrome; acute kidney injury; elderly.

Publication types

  • Multicenter Study

MeSH terms

  • Acute Coronary Syndrome / diagnostic imaging
  • Acute Coronary Syndrome / epidemiology*
  • Acute Coronary Syndrome / mortality
  • Acute Kidney Injury / blood
  • Acute Kidney Injury / diagnosis
  • Acute Kidney Injury / epidemiology*
  • Acute Kidney Injury / mortality
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Coronary Angiography / adverse effects
  • Creatinine / blood
  • Female
  • Humans
  • Incidence
  • Italy / epidemiology
  • Kaplan-Meier Estimate
  • Logistic Models
  • Male
  • Multivariate Analysis
  • Odds Ratio
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Time Factors

Substances

  • Biomarkers
  • Creatinine

Associated data

  • ClinicalTrials.gov/NCT00510185