Abstract
Radiopharmaceutical solutions of 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG) prepared via an aminopolyether-supported nucleophilic-substitution mechanism were analyzed for contaminant 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo-[8,8,8]-hexacosane (Kryptofix 2.2.2). Washing the C18-immobilized [18F]fluoro-tetraacetylated intermediate with 10 mL 0.1 M HCl was found to remove impurity Kryptofix 2.2.2 from the final product. Inclusion of this synthetic step allowed the robotic production of drug-quality 2-[18F]FDG in 52-56% radiochemical yield within 75 min. A thin-layer chromatographic system for the clinical screening of the radiochemical and chemical purity of this radiopharmaceutical is described.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bridged Bicyclo Compounds / isolation & purification*
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Bridged Bicyclo Compounds, Heterocyclic*
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Bridged-Ring Compounds / isolation & purification*
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Chelating Agents / isolation & purification
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Deoxy Sugars / chemical synthesis*
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Deoxyglucose / analogs & derivatives
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Deoxyglucose / chemical synthesis*
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Deoxyglucose / isolation & purification
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Drug Contamination
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Fluorine Radioisotopes
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Fluorodeoxyglucose F18
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Radiochemistry
Substances
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Bridged Bicyclo Compounds
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Bridged Bicyclo Compounds, Heterocyclic
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Bridged-Ring Compounds
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Chelating Agents
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Deoxy Sugars
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Fluorine Radioisotopes
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Fluorodeoxyglucose F18
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cryptating agent 222
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Deoxyglucose