Abstract
Two new sesquiterpenoid tropolone glycosides, liriosmasides A (1) and B (2), along with two known compounds, secoxyloganin and oplopanpheside C, were isolated from a methanol extract of the roots of Liriosma ovata. The structures of 1 and 2 were elucidated by spectroscopic methods including 1D and 2D NMR and by high-resolution mass spectrometry involving an ultra-high-performance liquid chromatography-quadrupole-orbital ion trap mass spectrometric (UHPLC-Q-Orbitrap MS) method. Compound 1 showed weak inhibitory activity against HIV RNase H.
MeSH terms
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Chromatography, High Pressure Liquid / methods
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Olacaceae / chemistry*
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Peru
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Plant Roots / chemistry
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Ribonuclease H / antagonists & inhibitors
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Tropolone / analogs & derivatives*
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Tropolone / chemistry
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Tropolone / isolation & purification*
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Tropolone / pharmacology
Substances
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Glycosides
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Sesquiterpenes
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liriosmaside A
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liriosmaside B
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oplopanpheside C
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Tropolone
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Ribonuclease H