Mycobacterium haemophilum bone and joint infection in HIV/AIDS: case report and literature review

Gail B Cross; Quynh Le; Brooke Webb; Grant A Jenkin; Tony M Korman; Michelle Francis; Ian Woolley

doi:10.1177/0956462414565403

Mycobacterium haemophilum bone and joint infection in HIV/AIDS: case report and literature review

Int J STD AIDS. 2015 Nov;26(13):974-81. doi: 10.1177/0956462414565403. Epub 2015 Jan 10.

Authors

Gail B Cross¹, Quynh Le², Brooke Webb³, Grant A Jenkin², Tony M Korman⁴, Michelle Francis³, Ian Woolley⁵

Affiliations

¹ Departments of Microbiology, Monash Health, Melbourne, Australia Infectious Diseases, Monash Health, Melbourne, VIC, Australia gailb.cross@gmail.com.
² Infectious Diseases, Monash Health, Melbourne, VIC, Australia.
³ Departments of Microbiology, Monash Health, Melbourne, Australia.
⁴ Departments of Microbiology, Monash Health, Melbourne, Australia Infectious Diseases, Monash Health, Melbourne, VIC, Australia Department of Medicine, Monash Health, Melbourne, VIC, Australia.
⁵ Infectious Diseases, Monash Health, Melbourne, VIC, Australia Department of Medicine, Monash Health, Melbourne, VIC, Australia Department of Infectious Diseases, Monash University, VIC, Australia.

PMID: 25577597
DOI: 10.1177/0956462414565403

Abstract

We report a case of disseminated Mycobacterium haemophilum osteomyelitis in a patient with advanced HIV infection, who later developed recurrent immune reconstitution inflammatory syndrome after commencement of antiretroviral therapy. We review previous reports of M. haemophilum bone and joint infection associated with HIV infection and describe the management of M. haemophilum-associated immune reconstitution inflammatory syndrome, including the role of surgery as an adjunctive treatment modality and the potential drug interactions between antiretroviral and antimycobacterial agents.

Keywords: HIV/AIDS; Mycobacterium haemophilum; immune reconstitution inflammatory syndrome; non-tuberculous mycobacteria; osteomyelitis.

Publication types

Case Reports
Review

MeSH terms

AIDS-Related Opportunistic Infections / diagnosis
AIDS-Related Opportunistic Infections / drug therapy*
AIDS-Related Opportunistic Infections / microbiology
Adult
Ankle Joint
Anti-Bacterial Agents / therapeutic use
Anti-HIV Agents / therapeutic use
Debridement
HIV Infections / complications*
HIV Infections / drug therapy
Humans
Immune Reconstitution Inflammatory Syndrome / complications*
Immune Reconstitution Inflammatory Syndrome / microbiology
Magnetic Resonance Imaging
Male
Middle Aged
Mycobacterium Infections / diagnosis*
Mycobacterium Infections / drug therapy
Mycobacterium Infections / microbiology
Mycobacterium haemophilum / genetics
Mycobacterium haemophilum / isolation & purification*
Osteomyelitis / diagnosis
Osteomyelitis / microbiology*
Osteomyelitis / therapy
Polymerase Chain Reaction
Tenosynovitis / microbiology
Tenosynovitis / surgery

Substances

Anti-Bacterial Agents
Anti-HIV Agents