Disseminated adenovirus disease in heart transplant recipient presenting with conjunctivitis

Transpl Infect Dis. 2015 Feb;17(1):125-8. doi: 10.1111/tid.12342. Epub 2015 Jan 9.

Abstract

We report a 65-year-old heart transplant recipient who presented with conjunctivitis, likely acquired from a family member who worked at a daycare center during an outbreak of conjunctivitis. He developed a severe adenoviral pneumonitis, which was successfully treated with intravenous cidofovir combined with a reduction of immunosuppression.

Keywords: adenovirus; cidofovir; conjunctivitis; heart transplantation; pneumonitis.

Publication types

  • Case Reports

MeSH terms

  • Adenovirus Infections, Human / drug therapy*
  • Adenoviruses, Human / drug effects
  • Aged
  • Antiviral Agents / therapeutic use*
  • Cidofovir
  • Conjunctivitis / drug therapy*
  • Cytosine / analogs & derivatives
  • Cytosine / therapeutic use
  • Heart Transplantation / adverse effects*
  • Humans
  • Immunocompromised Host
  • Immunosuppression Therapy / adverse effects
  • Male
  • Organophosphonates / therapeutic use
  • Pneumonia, Viral / drug therapy*
  • Postoperative Complications / drug therapy*
  • Transplant Recipients

Substances

  • Antiviral Agents
  • Organophosphonates
  • Cytosine
  • Cidofovir