Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy

Hao Zhang; Huixia Wu; Jun Wang; Yan Yang; Dongmei Wu; Yingjian Zhang; Yang Zhang; Zhiguo Zhou; Shiping Yang

doi:10.1016/j.biomaterials.2014.11.055

Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy

Biomaterials. 2015 Feb:42:66-77. doi: 10.1016/j.biomaterials.2014.11.055. Epub 2014 Dec 13.

Authors

Hao Zhang¹, Huixia Wu², Jun Wang¹, Yan Yang¹, Dongmei Wu³, Yingjian Zhang⁴, Yang Zhang¹, Zhiguo Zhou¹, Shiping Yang⁵

Affiliations

¹ The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China.
² The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China. Electronic address: wuhuixia@shnu.edu.cn.
³ Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China.
⁴ Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College & Center for Biomedical Imaging, Fudan University, Shanghai 200032, China.
⁵ The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China. Electronic address: shipingy@shnu.edu.cn.

PMID: 25542794
DOI: 10.1016/j.biomaterials.2014.11.055

Abstract

By using a solvothermal method in the presence of polyethylene glycol (PEG), BaGdF5 nanoparticles are firmly attached on the surface of graphene oxide (GO) nanosheets to form the GO/BaGdF5/PEG nanocomposites. The resulting GO/BaGdF5/PEG shows low cytotoxicity, positive magnetic resonance (MR) contrast effect and better X-ray attenuation property than Iohexol, which enables effective dual-modality MR and X-ray computed tomography (CT) imaging of the tumor model in vivo. The enhanced near-infrared absorbance, good photothermal stability and efficient tumor passive targeting of GO/BaGdF5/PEG result in the highly efficient photothermal ablation of tumor in vivo after intravenous injection of GO/BaGdF5/PEG and the following 808-nm laser irradiation (0.5 W/cm(2)). The histological and biochemical analysis data reveal no perceptible toxicity of GO/BaGdF5/PEG in mice after treatment. These results indicate potential application of GO/BaGdF5/PEG in dual-modality MR/CT imaging and photothermal therapy of cancers.

Keywords: BaGdF(5); Graphene oxide; Magnetic resonance imaging; Photothermal therapy; X-ray computed tomography imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Barium / pharmacology*
Barium Compounds / pharmacology
Cell Death / drug effects
Fluorides / pharmacology*
Gadolinium / pharmacology
Graphite / pharmacology*
HeLa Cells
Humans
Hyperthermia, Induced*
Magnetic Resonance Imaging
Mice
Mice, Nude
Multimodal Imaging*
Nanocomposites / chemistry*
Nanocomposites / ultrastructure
Neoplasms / pathology
Oxides / pharmacology*
Phototherapy*
Polyethylene Glycols / chemistry
Solutions
Spectroscopy, Fourier Transform Infrared
Spectroscopy, Near-Infrared
Tomography, X-Ray Computed
X-Ray Diffraction

Substances

Barium Compounds
Oxides
Solutions
Barium
Polyethylene Glycols
Graphite
Gadolinium
Fluorides