Objective: To study the association between metabolic syndrome(MS)and prognosis of endometrioid carcinoma.
Methods: A total of 256 patients with endometrioid carcinoma at, Zhejiang Cancer Hospital between January, 2001 and December, 2008 were chosen. The deadline for follow up was December 2008. The general conditions(including age and body mass index), whether coupled with MS and it's risk factors(including waist circumference, fasting plasma glucose, triglycerides, high- density lipoprotein, systolic and diastolic blood pressure) were analyzed. The outcome of 256 patients whether coupled with MS were analyzed using Kaplan-Meier curve. Relative risks were estimated using Cox proportional hazards regression model.
Results: A total of 256 cases were followed-up successfully.Sixty-four (33.0%) cases coupled with MS among the 194 patients survived, while thirty-two (51.6%) coupled with MS from 62 cases died, there was significant difference between them(χ² = 6.953, P = 0.008). The total five-year survival rate was 75.8%, the survival time was (78.0 ± 3.4) months. The rate and the survival time of patients coupled with MS [66.7%, (67.0 ± 2.4) months] were significantly lower than those coupled with no MS [81.3%, (85.0 ± 4.0) months; P < 0.05]. The Cox proportional hazards regression results showed that coupled with MS, body mass index ≥ 25 kg/m², waist circumference > 80 cm, abnormol systolic and diastolic blood pressure, abnormal fasting plasma glucose and more than two components of definitions of MS were related to bad prognosis of endometrioid carcinoma (P < 0.05).
Conclusion: Metabolic syndrome may be lead to a bad prognosis of endometrioid carcinoma.