Abstract
Two new (3, 4) and two known phenolic derivatives (1, 2) were isolated from Radix Astragali. The structures of 1-4 were elucidated by extensive spectroscopic analysis. The anti-inflammatory activities of the isolated compounds were evaluated in LPS-induced mouse peritoneal macrophages. All four compounds exhibited potent inhibitory effects on TNF-α production and TNF-α, COX-2, IL-1β, IL-6 and iNOS mRNA expression at 50 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / pharmacology*
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Astragalus propinquus
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Cells, Cultured
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Cyclooxygenase 2 / metabolism
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Drugs, Chinese Herbal / chemistry*
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Interleukin-1beta / metabolism
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Interleukin-6 / metabolism
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Macrophages / metabolism
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Mice
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Nitric Oxide Synthase Type II / metabolism
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Phenols / chemistry*
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Phenols / pharmacology*
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Anti-Inflammatory Agents
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Drugs, Chinese Herbal
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Interleukin-1beta
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Interleukin-6
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Lipopolysaccharides
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Phenols
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Tumor Necrosis Factor-alpha
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Huang Qi
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Nitric Oxide Synthase Type II
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Ptgs2 protein, mouse
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Cyclooxygenase 2