Leukocyte cell surface enzymology: CD45 (LCA, T200) is a protein tyrosine phosphatase

Immunol Today. 1989 Jul;10(7):225-8. doi: 10.1016/0167-5699(89)90257-0.

Abstract

During 1987, striking advances were made in defining the receptors and ligands for cell-to-cell adhesion interactions involving leukocytes. In 1988, two major leukocyte differentiation antigens, CD10 (cALLA) and CD45 (LCA, T200), were shown to be enzymes while two other markers, CD4 and CD8, were found to be associated with an enzyme. In this article, Ed Clark and Jeff Ledbetter discuss recent findings in the emerging area of leukocyte cell surface enzymology with emphasis on CD45, a membrane-associated protein tyrosine phosphatase (PTPase)2,3.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antigens, Differentiation / metabolism*
  • Histocompatibility Antigens / metabolism*
  • Humans
  • Leukocyte Common Antigens
  • Leukocytes / enzymology*
  • Phosphoprotein Phosphatases / metabolism*
  • Protein Tyrosine Phosphatases

Substances

  • Antigens, Differentiation
  • Histocompatibility Antigens
  • Phosphoprotein Phosphatases
  • Leukocyte Common Antigens
  • Protein Tyrosine Phosphatases