Single-layer transition metal dichalcogenide nanosheet-based nanosensors for rapid, sensitive, and multiplexed detection of DNA

Adv Mater. 2015 Feb 4;27(5):935-9. doi: 10.1002/adma.201404568. Epub 2014 Dec 12.

Abstract

Single-layer transition metal dichalcogenide nanosheets, including MoS2, TiS2, and TaS2, are used as novel sensing platforms for sensitive and selective detection of DNA, based on their high fluorescence-quenching ability and different affinities toward single-stranded DNA and double-stranded DNA. Importantly, for the first time, a single-layer TaS2 nanosheet-based multiplexed DNA sensor is also developed.

Keywords: DNA; fluorescence; multiplexed detection; nanosheets; transition metal dichalcogenides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / methods*
  • Chalcogens / chemistry*
  • DNA / analysis*
  • DNA / chemistry
  • DNA Probes / chemistry
  • Limit of Detection
  • Models, Molecular
  • Nanostructures / chemistry*
  • Nanotechnology / methods*
  • Nucleic Acid Conformation
  • Spectrometry, Fluorescence
  • Time Factors
  • Transition Elements / chemistry*

Substances

  • Chalcogens
  • DNA Probes
  • Transition Elements
  • DNA