Abstract
Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biological Transport
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Bombesin / metabolism
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Boron Compounds / chemistry
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Cell Line, Tumor
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Gold / chemistry*
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Humans
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Microscopy, Fluorescence
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Optical Imaging / methods*
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Organometallic Compounds / chemistry
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Organometallic Compounds / metabolism
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Organometallic Compounds / therapeutic use*
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Boron Compounds
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Organometallic Compounds
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Gold
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Bombesin